692/29 showed good anti-tumour responses in vivo and is a strong therapeutic candidate.
| Inventor | Institute |
|---|---|
| Mike Price | University of Nottingham |
| SKU: | 153394 |
|---|---|
| Product description: | MAbs targeting both Lewis(y) and Lewis(b) may have a therapeutic advantage over mAbs targeting just one hapten. 692/29 has a more restricted normal tissue distribution and a higher antigen threshold for killing which should reduce its toxicity compared to a Lewis(y) specific mAb. 692/29 has an ability to directly kill tumours whereas the anti-Lewis(b) mAb does not. This suggests that Lewis(y) but not Lewis(b) are functional glycans. 692/29 showed good anti-tumour responses in vivo and is a strong therapeutic candidate. |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Immunogen: | Tumor cells |
| Cat. #: | 153394 |
|---|---|
| Provenance and Ownership: | The Anti-Lewis Y [C14] is owned by Cancer Research UK. CancerTools supplies the Anti-Lewis Y [C14] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-Lewis Y [C14] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Genetics |
| Application: | ELISA ; FACS ; IHC |
| Target: | Lewis Y |
| Reactivity: | Human |
| Clone: | C14 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | MAbs targeting both Lewis(y) and Lewis(b) may have a therapeutic advantage over mAbs targeting just one hapten. 692/29 has a more restricted normal tissue distribution and a higher antigen threshold for killing which should reduce its toxicity compared to a Lewis(y) specific mAb. 692/29 has an ability to directly kill tumours whereas the anti-Lewis(b) mAb does not. This suggests that Lewis(y) but not Lewis(b) are Fn glycans. 692/29 showed good anti-tumour responses in vivo and is a strong therapeutic candidate. |
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| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Durrant et al. 1989. J Natl Cancer Inst. 81(9):688-96. PMID: 2468779. Flow cytometric screening of monoclonal antibodies for drug or toxin targeting to human cancer. |
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