UCH-T2 is useful for detection of T cells in peripheral blood and lymph nodes and categorisation of T cell lymphomas and B cell chronic lymphocytic leukaemia.
| Inventor | Institute |
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| Peter Beverley | University College London (UCL) |
| SKU: | 151176 |
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| Product description: | UCH-T2 is useful for detection of T cells in peripheral blood and lymph nodes and categorisation of T cell lymphomas and B cell chronic lymphocytic leukaemia. |
| Alternate name: | CD5 Molecule 2; Lymphocyte Antigen T1/Leu-1; LEU1; CD5 Antigen; T1 |
| Additional notes: | UCH-T1TM a registered trademark of Cancer Research Technology, Limited. All rights reserved. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Immunogen: | Thymocytes followed by Sezary T cells. |
| Immunogen Uniprot ID: | P04234 |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Cat. #: | 151176 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Blood cancer |
| Research Fields: | Immunology;Stem cell biology |
| Application: | IHC ; IF ; WB |
| Target: | Leu1 (CD5) |
| Reactivity: | Human |
| Clone: | UCH-T2 |
| Host: | Mouse |
| Class: | Monoclonal |
| Primary citation: | Beverley & Callard. 1982. Protides Biol Fluids. 29:653-8. |
| Target background: | Leu-1 is a surface glycoprotein present on peripheral T cells (>95%) and B-cell chronic lymphocytic leukaemia cells that binds CD72. Absence of the Leu-1 marker on childhood ALL cells is associated with a more favourable prognosis. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Beverley PE & Callard RE. 1982. Protides Biol. Fluids. Colloq. 29:653-8. Kap et al. 2009. J Histochem Cytochem. 57(12):1159-67. PMID: 19729671. A monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates. Gary-Gouy et al. 2007. J Immunol. 179(7):4335-44. PMID: 17878328. Natural phosphorylation of CD5 in chronic lymphocytic leukemia B cells and analysis of CD5-regulated genes in a B cell line suggest a role for CD5 in malignant phenotype. |
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