Anti-Lamin B receptor [BB2SS3F3]

Lamin B Receptor (LBR) is a polytopic inner nuclear membrane protein. Its nucleoplasmic domain interacts with components of the nuclear lamina as well as with chromatin, via HP1. LBR also exhibits C14 sterol reductase activity. Deficiency of LBR in humans results in Pelget-Hu??t anomaly featuring hypolobulated granulocyte nuclei. Homozygous loss of LBR causes Greenberg skeletal […]

Contributors

Institute
A*STAR Accelerate Technologies Pte Ltd
Cat. #: 153492
Unit size: 100 ug
Research Fields: Cell signaling and signal transduction
Application: IHC; IF ; WB
Target: Lamin B receptor
Reactivity: Human ; Mouse
Clone: BB2SS3F3
Host: Mouse
Class: Monoclonal
Alternate name: DHCR 14B antibody, DHCR14B antibody, Integral nuclear envelope inner membrane protein antibody, Lamin-B receptor antibody, LBR antibody, LBR_HUMAN antibody, LMN 2R antibody, LMN2R antibody, MGC941 antibody, PHA antibody, PRO65 antibody
Product description: Lamin B Receptor (LBR) is a polytopic inner nuclear membrane protein. Its nucleoplasmic domain interacts with components of the nuclear lamina as well as with chromatin, via HP1. LBR also exhibits C14 sterol reductase activity. Deficiency of LBR in humans results in Pelger-Huët anomaly featuring hypolobulated granulocyte nuclei. Homozygous loss of LBR causes Greenberg skeletal dysplasia a fetal lethal disorder associated with defective cholesterol metabolism.
Conjugation: Unconjugated
Isotype: IgG1 kappa
Immunogen: GST fused to N-terminal fragment of human LBR (amino acids residues 1-211)
Myeloma used: Sp2/0-Ag14
Target background: Lamin B Receptor (LBR) is a polytopic inner nuclear membrane protein. Its nucleoplasmic domain interacts with components of the nuclear lamina as well as with chromatin, via HP1. LBR also exhibits C14 sterol reductase activity. Deficiency of LBR in humans results in Pelger-Huët anomaly featuring hypolobulated granulocyte nuclei. Homozygous loss of LBR causes Greenberg skeletal dysplasia a fetal lethal disorder associated with defective cholesterol metabolism.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice

Images

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Western blot analysis of BB2SS3F3 antibody. Whole cell lysate from human (Hela) and mouse (C2C12; immortalized mouse adult fibroblasts (MAFs); NIE-115) cell lines were separated on SDS-PAGE gel; transferred to nitrocellulose membrane and blotted with BB2SS3F3 antibody. Both primary and secondary antibodies were diluted in blocking buffer (5% nonfat dry milk resuspended in 0.1% Tween and 1X PBS). The predicted molecular weight is 70.7kDA and 71.4kDa for human and mouse LBR respectively. The absence of a band in LBR null MAFs indicated that the antibody specifically recognizes LBR.

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