Anti-Keratin6 [LHK6]

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Contributors

Inventor Institute
Nick Tidman Queen Mary University of London
SKU: 151440
Product description: LHK6 is a very good marker for hyperproliferative keratinocytes.
Alternate name: CK6A, CK6B, CK6C, CK6D, CK6E, Keratin Type II Cytoskeletal 6A, Keratin Type II Cytoskeletal 6B, Keratin Type II Cytoskeletal 6C, Keratin Type II Cytoskeletal 6D, Keratin Type II Cytoskeletal 6E, KRT6, KRT6A, KRT6B, KRT6C, KRT6D, KRT6EHuman Entrez Gene ID 3853-KRT6A, 3854-KRT6B, 286887-KRT6C Human SwissProt P2538-KRT6A, P4259-KRT6B, P48668-KRT6C Human Unigene 7779 Human Gene Symbol KRT6A; KRT6B; KRT6CHuman Chromosome Location 12q13.13; 12q13.13; 12q13.13
Conjugation: Unconjugated
Isotype: IgG2a kappa
Molecular weight: 55-57 kDa
Immunogen: 11 amino aid sequence GSSTIKYTTTS of K6b C terminal
Myeloma used: Sp2/0-Ag14
Cat. #: 151440
Provenance and Ownership: The Anti-Keratin6 [LHK6] is owned by Cancer Research UK. CancerTools supplies the Anti-Keratin6 [LHK6] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-Keratin6 [LHK6] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements.
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cell signaling and signal transduction
Application: ELISA ; FACS ; IHC ; IF ; WB
Target: Keratin 6
Reactivity: Human ; Mouse
Clone: LHK6
Host: Mouse
Class: Monoclonal
Target background: Clone LHK6 recognizes a protein of 56kDa, identified as cytokeratin 6 (CK6). In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns. Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratin 9 to 23) and on type II kerating (1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratins 6,16 and 17 are expressed in suprabasasl keratinocytes of wounded epidermis. Keratin 6 is found in acrosyringeal keratinocyes in normal skin.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Toivola et al. 2002. Mol Biol Cell. 13(6):1857-70. PMID: 12058054.

Type II keratins are phosphorylated on a unique motif during stress and mitosis in tissues and cultured cells.

Porter et al. 2000. Lab Invest. 80(11):1701-10. PMID: 11092530.

K15 expression implies lateral differentiation within stratified epithelial basal cells.

Machesney et al. 1998. Am J Pathol. 152(5):1133-41. PMID: 9588880.

Activated keratinocytes in the epidermis of hypertrophic scars.

Wetzels et al. 1991. Am J Pathol. 138(3):751-63. PMID: 1705754.

Basal cell-specific and hyperproliferation-related keratins in human breast cancer.

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