Anti-Keratin18 [LDK18]

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Contributors

Inventor Institute
Birgit Lane University of Dundee
SKU: 151317
Product description: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratins 8 and 18 are two of the first keratins expressed in the embryo, and persist into adult tissues as the keratin pair representing minimal epithelial keratin expression. Keratins 8 and 18 are major components of all simple epithelia (but not of stratified squamous epithelia) and adenocarcinomas.
Conjugation: Unconjugated
Isotype: IgG1 kappa
Immunogen: Synthetic peptide of human keratin 18 (CSETNDTKVLRH-COOH)
Cat. #: 151317
Provenance and Ownership: The Anti-Keratin18 [LDK18] is owned by Cancer Research UK. CancerTools supplies the Anti-Keratin18 [LDK18] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-Keratin18 [LDK18] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements.
Unit size: 100 ug
Research Fields: Cell signaling and signal transduction
Application: ELISA ; FACS ; IHC ; IF ; IP ; WB
Target: Keratin 18
Reactivity: Human ; Mouse ; Pig
Clone: LDK18
Host: Mouse
Class: Monoclonal
Target background: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratins 8 and 18 are two of the first keratins expressed in the embryo, and persist into adult tissues as the keratin pair representing minimal epithelial keratin expression. Keratins 8 and 18 are major components of all simple epithelia (but not of stratified squamous epithelia) and adenocarcinomas.
Format: Liquid
Concentration: 1mg/ml
Storage buffer: DMEM + 5% FCS
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Hosoya A et al. Anat Rec (Hoboken). 2010 Nov

293(11):1864-72. PMID: 20818615 D'Alessandro M et al. J Invest Dermatol. 2011 Jul

131(7):1412-9. PMID: 21326298

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