| Inventor | Institute |
|---|---|
| Nick Tidman | Queen Mary University of London |
| SKU: | 151242 |
|---|---|
| Product description: | Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 15 is a type I keratin which is expressed only in basal keratinocytes in stratified epithelia and does not appear to have a natural type II expression partner. Keratin 15 is down regulated in activated keratinocytes. |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Immunogen: | Peptide sequence of keratin 15 – BSA conjugate |
| Myeloma used: | Sp2/0-Ag14 |
| Cat. #: | 151242 |
|---|---|
| Provenance and Ownership: | The Anti-Keratin15 [LHK15] is owned by Cancer Research UK. CancerTools supplies the Anti-Keratin15 [LHK15] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-Keratin15 [LHK15] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | 10XUAS IVS p10 |
| Unit size: | 100 ug |
| Research Fields: | Cell signaling and signal transduction |
| Application: | ELISA ; FACS ; IHC ; IF ; IP ; WB |
| Target: | Keratin 15 |
| Reactivity: | Bovine ; Human ; Mouse ; Rat |
| Clone: | LHK 15 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 15 is a type I keratin which is expressed only in basal keratinocytes in stratified epithelia and does not appear to have a natural type II expression partner. Keratin 15 is down regulated in activated keratinocytes. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | DMEM + 5-10% FCS |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Waseem A et al. 1999. J. Invest. Dermatol. 112:362-9. PMID: 10084315 Porter RM et al. 2000. Lab Invest. 80(11):1701-10. PMID: 11092530 Inoue K et al. Lab Invest. 2009 Aug 89(8):844-56. PMID: 19506554 |
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