| Inventor | Institute |
|---|---|
| Jenny Southgate | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| SKU: | 151742 |
|---|---|
| Product description: | Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratins 7 and 8 are two closely related type II keratins characteristic of simple epithelia. Keratin 7 is less widespread than keratin 8 and is expressed in sebaceous and sweat glands and some cells of the inner hair root sheath. Keratin 7 is often co-expressed with keratin 19. LdS 65 is useful for studies of epithelial cells and tumour origin. |
| Conjugation: | Unconjugated |
| Isotype: | Not Known |
| Immunogen: | Cytoskeletons of the human urothelial RT4 cell line |
| Cat. #: | 151742 |
|---|---|
| Provenance and Ownership: | The Anti-Keratin 7 & 8 [LDS65] is owned by Cancer Research UK. CancerTools supplies the Anti-Keratin 7 & 8 [LDS65] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-Keratin 7 & 8 [LDS65] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell signaling and signal transduction |
| Application: | IHC |
| Target: | Keratin 7 and Keratin 8 |
| Reactivity: | Human |
| Clone: | LDS65 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratins 7 and 8 are two closely related type II keratins characteristic of simple epithelia. Keratin 7 is less widespread than keratin 8 and is expressed in sebaceous and sweat glands and some cells of the inner hair root sheath. Keratin 7 is often co-expressed with keratin 19. LdS 65 is useful for studies of epithelial cells and tumour origin. |
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| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Southgate et al. 1987. Lab Invest. 56(2):211-23. PMID: 2433501. Primary culture of human oral epithelial cells. Growth requirements and expression of differentiated characteristics. Trejdosiewicz et al. 1986. Exp Cell Res. 164(2):388-98. PMID: 2423348. Phenotypic analysis of cultured melanoma cells. Expression of cytokeratin-type intermediate filaments by the M5 human melanoma cell line. |
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