Anti-Integrin alpha3 (CD49c) monoclonal antibody [KU44.22B]

diagnostic and therapeutic potential in addition it will be a valuable tool for unravelling the role of integrin ?3 and CD26 in the progression and complex biology of pancreatic cancer

Contributors

Inventor Institute
Helmout Modjtahedi Kingston University
SKU: 161583
Product description: MAb KU44.22B inhibits the growth in vitro of Capan-2 cancer cells, increases migration of BxPC-3 and CFPAC-1 cancer cell lines and induces receptor downregulation and internalisation
Isotype: IgG1 kappa
Molecular weight: 110 kDa
Immunogen: CFPAC-1 cell line
Cat. #: 161583
Tool sub type: Primary antibody
Research Fields: Cancer
Application: ELISA, IHC, IF, IP, WB, FACS
Target: Integrin alpha3
Reactivity: Human
Clone: KU44.22B
Host: Mouse
Class: Monoclonal
Primary citation: Arias-Pinilla et al. 2020. Sci Rep. 10(1):537. PMID: 31953437
Target background: Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion.
Shipping conditions: Dry ice
References:

Arias-Pinilla et al. 2020. Sci Rep. 10(1):537. PMID: 31953437

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