Anti-Integrin alpha 6 [MP4F10]

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A mouse monoclonal antibody recognising human integrin alpha 6/CD49f, used to study laminin-binding integrins, cell adhesion and epithelial cell biology.

Contributors

Inventor Institute
Walter Bodmer Cancer Research UK, London Research Institute: Lincoln's Inn Fields
SKU: 151134
Product description: Anti-Integrin alpha 6 [MP4F10] is a mouse monoclonal antibody that recognises human integrin alpha 6/CD49f. It is used to detect and study laminin-binding integrins, supporting research into cell adhesion, epithelial and endothelial basement membrane interactions, and integrin-mediated signalling. Integrin alpha 6 associates with integrin beta 4 to form alpha 6 beta 4, a major keratinocyte laminin receptor.
Additional notes: MP 4F10 may be used in clinical studies for tumour grading as it will stain both moderately and well-differentiated colorectal adenocarcinoma.
Conjugation: Unconjugated
Isotype: IgG1 kappa
Molecular weight: 118/100
Immunogen: SW1222 human colorectal cell line.
Myeloma used: P3/NS1/1-Ag4.1
Cat. #: 151134
Provenance and Ownership: The Anti-Integrin alpha 6 [MP4F10] is owned by Cancer Research UK. CancerTools supplies the Anti-Integrin alpha 6 [MP4F10] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-Integrin alpha 6 [MP4F10] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements.
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cell biology;Developmental biology;Stem cell biology
Application: IF ; ICC ; FACS ; IHC ; IP ; WB
Target: Integrin alpha6 (CD49f)
Reactivity: Human
Clone: MP4F10
Host: Mouse
Class: Monoclonal
Primary citation: Pignatelli et al. 1990. Proc Natl Acad Sci U S A. 87(4):1541-5. PMID: 2304917.
Target background: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha 6 is found on epithelial and endothelial basement membranes and colorectal carcinoma. Integrin alpha 6 associates with integrin beta 4 to form integrin a6b4, one of the most abundant keratinocyte integrins, and binds laminin.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Zhou et al. 2019. Stem Cell Res Ther. 10(1):155. PMID: 31151466.

Pieri et al. 2019. Stem Cell Res Ther. 10(1):135. PMID: 31109365.

Kapsokalyvas et al. 2017. Colloids Surf B Biointerfaces. 159:97-107. PMID: 28780465.

Zhang et al. 2017. PLoS One. 12(2):e0172207. PMID: 28234938.

Zhang et al. 2016. Cell Reprogram. 18(6):401-410. PMID: 27906584.

Al Thawadi et al. 2016. Oncotarget. 7(5):5289-305. PMID: 26700621.

Stempin et al. 2015. Cancer Cell Int. 15:110. PMID: 26612978.

Svensson Mnsson et al. 2007. J Pathol. 212(1):102-11. PMID: 17370299.

Levy et al. 2000. Mol Biol Cell. 11(2):453-66. PMID: 10679006.

Anbazhagan et al. 1995. J Pathol. 176(3):227-32. PMID: 7674085.

Pignatelli et al. 1990. Proc Natl Acad Sci U S A. 87(4):1541-5. PMID: 2304917.

Images

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a6 chain showed positive staining of the basement membrane domain of basal cells and either weak positive or negative staining of the luminal epithelial cells (Fig. 3). (ANBAZHAGAN et al. JOURNAL OF PATHOLOGY; VOL. 176 227-232 (1995))

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