Anti-Integrin alpha 3 [F35 177-1]

Integrins are heterodimeric cell surface receptors composed of a and b subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin a3 is found on most cell types. Integrin a3 associates with b1 integrin to form integrin a3b1, which is one of the most abundant keratinocyte integrins and binds laminin 5.

Contributors

Inventor Institute
Joyce Taylor-Papadimitriou Cancer Research UK, London Research Institute: Lincoln's Inn Fields
SKU: 151096
Product description: Integrins are heterodimeric cell surface receptors composed of a and b subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin a3 is found on most cell types. Integrin a3 associates with b1 integrin to form integrin a3b1, which is one of the most abundant keratinocyte integrins and binds laminin 5.
Conjugation: Unconjugated
Isotype: IgG1 kappa
Molecular weight: 14 kDa
Immunogen: MTSV1-7 HYE – human breast epithelial cells.
Myeloma used: P3X63Ag8.653
Cat. #: 151096
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer; Cell biology
Application: IHC ; IF
Target: Integrin a3 (CD49c)
Reactivity: Human
Clone: F35 177-1
Host: Mouse
Class: Monoclonal
Primary citation: Gaggioli et al. 2007. Nat Cell Biol. 9(12):1392-400. PMID: 18037882.
Target background: Integrins are heterodimeric cell surface receptors composed of a and b subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin a3 is found on most cell types. Integrin a3 associates with b1 integrin to form integrin a3b1, which is one of the most abundant keratinocyte integrins and binds laminin 5.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Lustosa et al. 2014. ScientificWorldJournal. 2014:102541. PMID: 24737953.

Expression profiling using a cDNA array and immunohistochemistry for the extracellular matrix genes FN-1, ITGA-3, ITGB-5, MMP-2, and MMP-9 in colorectal carcinoma progression and dissemination.

McInroy et al. 2011. Exp Cell Res. 317(17):2468-78. PMID: 21821021.

Plectin regulates invasiveness of SW480 colon carcinoma cells and is targeted to podosome-like adhesions in an isoform-specific manner.

Gaggioli et al. 2007. Nat Cell Biol. 9(12):1392-400. PMID: 18037882.

Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells.

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