Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. Integrin ?3 (P1B5) is a mouse monoclonal antibody developed to identify four distinct classes (I, II, III, IV) of cell surface receptors for native collagen. P1B5 inhibited attachment to type VI and I collagens and partially inhibited attachment to fibronectin and laminin as well.
| Inventor | Institute |
|---|---|
| Elizabeth A. Wayner, William Carter | Fred Hutchinson Cancer Center |
| Cat. #: | 161656 |
|---|---|
| Tool sub type: | Primary antibody |
| Research Fields: | Cell biology |
| Application: | FACS, Function Blocking, Immunofluorescence, Immunohistochemistry, Immunoprecipitation |
| Target: | Integrin alpha-3 (CD49b) |
| Reactivity: | Human |
| Clone: | P1B5 |
| Host: | Mouse |
| Class: | Monoclonal |
| Primary citation: | Wayner et al.1987. Journal of Cell Biology.105(4):1873-84. PMID: 2822727 |
| Product description: | Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. Integrin ?3 (P1B5) is a mouse monoclonal antibody developed to identify four distinct classes (I, II, III, IV) of cell surface receptors for native collagen. P1B5 inhibited attachment to type VI and I collagens and partially inhibited attachment to fibronectin and laminin as well. |
|---|---|
| Isotype: | IgG1 |
| Molecular weight: | 119kDa |
| Immunogen: | HT1080 human fibrosarcoma cell line |
| Target background: | ?2?1 complex of Collagen receptors: I, II, III, IV. P1B5 inhibits cell adhesion to collagen and fibronectin. |
|---|
| Storage conditions: | For immediate use, short term storage at 4°C up to two weeks is recommended. For long term storage, divide the solution into volumes of no less than 20 ul for freezing at -20°C or -80°C. The small volume aliquot should provide sufficient reagent for short term use. Freeze-thaw cycles should be avoided. For concentrate or bioreactor products, an equal volume of glycerol, a cryoprotectant, may be added prior to freezing. |
|---|---|
| Shipping conditions: | Dry ice |
| References: |
Wayner et al.1987. Journal of Cell Biology.105(4):1873-84.PMID: 2822727 Carter et al.1990. J Cell Biol.111(6 ):3141-54.PMID: 2269668 Symington et al. 1993.J Cell Biol.120(2):523-35.PMID: 8421064 |
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