Anti-Integrin a2 [HAS-3]

Exclusive tool

Monoclonal antibody which co-precipitates a2b1 integrin from keratinocytes and inhibits a2b1 motility in collagen.

Contributors

Inventor Institute
Fiona Watt Cancer Research UK, London Research Institute: Lincoln's Inn Fields
SKU: 151104
Product description: Monoclonal antibody which co-precipitates a2b1 integrin from keratinocytes and inhibits a2b1 motility in collagen.
Alternate name: Integrin Subunit Alpha 2; Alpha 2 Subunit Of VLA-2 Receptor; Platelet Membrane Glycoprotein Ia; CD49 Antigen-Like Family Member B; Collagen Receptor; CD49B; GPIa; Very Late Activation Protein 2 Receptor, Alpha-2 Subunit; Human Platelet Alloantigen System 5; Platelet Glycoprotein GPIa; Platelet Antigen Br; VLA-2 Subunit Alpha; CD49b Antigen; HPA-5; VLA-2; VLAA2; BR
Conjugation: Unconjugated
Isotype: IgG2a
Immunogen: Whole human keratinocytes.
Immunogen Uniprot ID: P17301
Myeloma used: Sp2/0-Ag14
Cat. #: 151104
Provenance and Ownership: The Anti-Integrin a2 [HAS-3] is owned by Cancer Research UK. CancerTools supplies the Anti-Integrin a2 [HAS-3] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-Integrin a2 [HAS-3] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements.
Tool sub type: Primary antibody
Unit size: 100 ug
Application: FACS ; IHC ; IF ; IP
Target: Integrin a2 (CD49b)
Reactivity: Human
Clone: HAS-3
Host: Mouse
Class: Monoclonal
Target background: Monoclonal antibody which co-precipitates a2b1 integrin from keratinocytes and inhibits a2b1 motility in collagen.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
Shipping conditions: Dry ice
References:

Activation of c-MET induces a stem-like phenotype in human prostate cancer.

van Leenders et al. 2011. PLoS One. 6(11):e26753. PMID: 22110593.

Teklemariam et al. 2011. Toxicon. 57(5):646-56. PMID: 21255601.

Fn analysis of a recombinant PIII-SVMP, GST-acocostatin

an apoptotic inducer of HUVEC and HeLa, but not SK-Mel-28 cells.

Singh et al. 2010. Am J Physiol Lung Cell Mol Physiol. 299(2):L169-83. PMID: 20435685.

Can lineage-specific markers be identified to characterize mesenchyme-derived cell populations in the human airways?

Alford et al. 1998. J Cell Sci. 111 ( Pt 4):521-32. PMID: 9443900.

Integrin-matrix interactions affect the form of the structures developing from human mammary epithelial cells in collagen or fibrin gels.

Tenchini et al. 1993. Cell Adhes Commun. 1(1):55-66. PMID: 7521749.

Evidence against a major role for integrins in calcium-dependent intercellular adhesion of epidermal keratinocytes.

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Adapted from van Leenders et al. 2011. PLoS One. 6(11)

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