The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6.
| Inventor | Institute |
|---|---|
| Arnoud Sonnenberg | Netherlands Cancer Institute |
| Cat. #: | 154740 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology;Cell signaling and signal transduction |
| Application: | IHC ; WB |
| Target: | Integrin a6A |
| Reactivity: | Human |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | ITGA6; CD49F Antigen; VLA-6 |
|---|---|
| Product description: | The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Specific loss of this integrin chain in the intestinal epithelium, and thus of their hemidesmosomes, induces long-standing colitis and infiltrating adenocarcinomas. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | A mouse was immunized with a synthetic peptide corresponding to the C terminal 28 amino acids of integrin a6A including an appending N-terminal cysteine (CKKDHYDATYHKAEIHAQPSDKERLTSDA) coupled to keyhole limpet hemocyanin. |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Specific loss of this integrin chain in the intestinal epithelium, and thus of their hemidesmosomes, induces long-standing colitis and infiltrating adenocarcinomas. |
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| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Hogervorst et al. 1993. J Cell Biol. 121(1):179-91. PMID: 7681434. |
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