Anti-IL31

The antibody will elucidate the role of IL-31 in horse and shed further light on its clinical significance.

Contributors

Inventor Institute
Abdo Alnabulsi Vertebrate Antibodies Limited
SKU: 158055
Product description: IL-31 is an inflammatory cytokine that modulates cell-mediated immunity against pathogens. It is produced by activated CD4+ T lymphocytes, in particular activated Th2 helper cells, mast cells, macrophages, and dendritic cells. It’s major sites of action are the skin, lung, intestine and the nervous system. IL-31 signals via a receptor complex that is composed of IL-31 receptor A (IL31RA) and oncostatin M receptor (OSMR) subunits. These receptor subunits are expressed in activated monocytes and in unstimulated epithelial cells. It was reported when IL-31 is overexpressed in transgenic mice, it results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development. IL-31 and its receptors are also involved in regulating hematopoietic progenitor cell homeostasis.The antibody will elucidate the role of IL-31 in horse and shed further light on its clinical significance.
Conjugation: Unconjugated
Molecular weight: 17.7 kDa
Immunogen: Ovalbumin-conjugated synthetic peptide
Cat. #: 158055
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cell biology; Immunology
Application: ELISA ; WB
Target: Interleukin 31
Reactivity: Horse
Host: Rabbit
Class: Polyclonal
Target background: IL-31 is an inflammatory cytokine that modulates cell-mediated immunity against pathogens. It is produced by activated CD4+ T lymphocytes, in particular activated Th2 helper cells, mast cells, macrophages, and dendritic cells. It’s major sites of action are the skin, lung, intestine and the nervous system. IL-31 signals via a receptor complex that is composed of IL-31 receptor A (IL31RA) and oncostatin M receptor (OSMR) subunits. These receptor subunits are expressed in activated monocytes an…
Format: Liquid
Storage buffer: Unpurified anti-serum from rabbit preserved in 0.02% Thiomersal
Shipping conditions: Dry ice

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