ICAMs are members of the immunoglobulin superfamily that is characterised by the presence of immunoglobulin-like domains. ICAM-1 is expressed in haemopoietic cells and vascular endothelium. Cytokine activation causes ICAM-1 expression in other cell types such as fibroblasts and keratinocytes. ICAM-1 is involved in leukocyte recruitment and inflammation. ICAM-1 binds LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). P1W16 may be useful for prognosis of malignant melanoma.
| Inventor | Institute |
|---|---|
| Deborah Buckle ; John Marshall | Queen Mary University of London |
| SKU: | 151290 |
|---|---|
| Product description: | ICAMs are members of the immunoglobulin superfamily that is characterised by the presence of immunoglobulin-like domains. ICAM-1 is expressed in haemopoietic cells and vascular endothelium. Cytokine activation causes ICAM-1 expression in other cell types such as fibroblasts and keratinocytes. ICAM-1 is involved in leukocyte recruitment and inflammation. ICAM-1 binds LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). P1W16 may be useful for prognosis of malignant melanoma. |
| Alternate name: | Intercellular Adhesion Molecule 1; Major Group Rhinovirus Receptor; ICAM-1; Cell Surface Glycoprotein P3.58; Human Rhinovirus Receptor; P3.58; CD54; BB2 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Molecular weight: | 85-115 |
| Immunogen: | V(+)B2- Human Ocular melanoma line |
| Cat. #: | 151290 |
|---|---|
| Provenance and Ownership: | The Anti-ICAM1 [P1W16] is owned by Cancer Research UK. CancerTools supplies the Anti-ICAM1 [P1W16] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-ICAM1 [P1W16] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Unit size: | 100 ug |
| Research Fields: | Cell biology; Immunology; Stem cell biology; Tissue-specific biology |
| Application: | FACS ; IHC ; IF ; IP |
| Target: | ICAM1 (CD54) |
| Reactivity: | Human |
| Clone: | P1W16 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | ICAMs are members of the immunoglobulin superfamily that is characterised by the presence of immunoglobulin-like domains. ICAM-1 is expressed in haemopoietic cells and vascular endothelium. Cytokine activation causes ICAM-1 expression in other cell types such as fibroblasts and keratinocytes. ICAM-1 is involved in leukocyte recruitment and inflammation. ICAM-1 binds LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). P1W16 may be useful for prognosis of malignant melanoma. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9mg/ml |
| Storage buffer: | DMEM + 5% FCS |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
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