Ataxin-3 is a deubiquitinating enzyme involved in the clearance of misfolded proteins. The enzyme functions in proteasome degradation and autophagy. Mutated forms of Ataxin-3 can lead to misfolded protein aggregation which cause the neurodegenerative disorder spinocerebellar ataxia type-3 (SCA3), also known as Machado-Joseph disease.
| Inventor | Institute |
|---|---|
| Patrick Loll | Drexel University |
| SKU: | 156506 |
|---|---|
| Product description: | Ataxin-3 is a deubiquitinating enzyme involved in the clearance of misfolded proteins. The enzyme functions in proteasome degradation and autophagy. Mutated forms of Ataxin-3 can lead to misfolded protein aggregation which cause the neurodegenerative disorder spinocerebellar ataxia type-3 (SCA3), also known as Machado-Joseph disease. |
| Alternate name: | Machado-Joseph Disease (MJD) Protein 1; Spinocerebellar Ataxia Type 3 |
| Conjugation: | Unconjugated |
| Molecular weight: | 42 kDa |
| Immunogen: | Recombinant Human Ataxin-3 |
| Immunogen Uniprot ID: | ATX3_HUMAN |
| Cat. #: | 156506 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Biochemistry;Neurobiology |
| Application: | ELISA ; IP |
| Target: | Ataxin-3 |
| Reactivity: | Human |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Ataxin-3 is a deubiquitinating enzyme involved in the clearance of misfolded proteins. The enzyme functions in proteasome degradation and autophagy. Mutated forms of Ataxin-3 can lead to misfolded protein aggregation which cause the neurodegenerative disorder spinocerebellar ataxia type-3 (SCA3), also known as Machado-Joseph disease. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
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