Anti-HSVUL42 [2H4]

2H4 may be used to detect UL42 bound to HSV polymerase. Recognises amino acids 360-366 in UL42.

Contributors

Inventor Institute
Diane Wilcock Cancer Research UK, London Research Institute: Clare Hall Laboratories
Cat. #: 151043
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Microbiology
Application: IF ; WB ; ICC ; ELISA ; IHC ; IF ; IP ; WB
Target: Herpes Simplex Virus protein UL42 (HSV-UL42)
Reactivity: Virus
Clone: 2H4
Host: Mouse
Class: Monoclonal
Alternate name: Fucosyltransferase 4; Galactoside 3-L-Fucosyltransferase; ELAM-1 Ligand Fucosyltransferase; FUC-TIV; FCT3A; ELFT; Stage-Specific Embryonic Antigen; Alpha (1,3) Fucosyltransferase; EC 2.4.1.65; Lewis X; SSEA-1; FUTIV; CD15; LeX
Product description: 2H4 may be used to detect UL42 bound to HSV polymerase. Recognises amino acids 360-366 in UL42.
Conjugation: Unconjugated
Isotype: IgG1
Immunogen: Baculovirus-expressed HSV DNA polymerase (POL) and POL/UL42 complex.
Immunogen Uniprot ID: P22083
Myeloma used: Sp2/0-Ag14
Target background: UL42 is the DNA polymerase accessory protein of herpes simplex virus type 1.
Format: Liquid
Concentration: 1.1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Lv et al. 2018. Antiviral Res. 159:55-62. PMID: 30266338.

Dhner et al. 2018. PLoS Pathog. 14(1):e1006823. PMID: 29304174.

Dembowski et al. 2017. PLoS Pathog. 13(1):e1006166. PMID: 28095497.

Chen et al. 2007. J Virol. 81(16):8742-51. PMID: 17553899.

Chen et al. 2007. J Virol. 81(16):8742-51. PMID: 17553899.

A mutation in the human herpes simplex virus type 1 UL52 zinc finger motif results in defective primase activity but can recruit viral polymerase and support viral replication efficiently.

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Adapted from Chen Y; Livingston CM; Carrington-Lawrence SD; Bai P; Weller SK. A mutation in the human herpes simplex virus type 1 UL52 zinc finger motif results in defective primase activity but can recruit viral polymerase and support viral replication efficiently. J Virol. 2007 Aug;81(16)

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