A site specific polyclonal antibody for HSPB4; works after aldehyde fixation; retinoblastoma; small heat shock protein protects cells aginst apoptosis
| Inventor | Institute |
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| Roy Quinlan | University of Durham |
| SKU: | 162215 |
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| Product description: | A polyclonal antibody for HSPB4 also known as Alpha-crystallin A chain or CRYAA. This target is a major lens structural protein, which has shown increased expression in retinoblastoma as compared to healthy retina. It acts as a molecular chaperone and anti-apoptotic regulator. This HSPB4 antibody recognises an epitope in the N-terminal of the protein. Antibody functions after aldehydye fixation. |
| Alternate name: | Alpha-crystallin A chain, CRYA1,CRYAA |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Molecular weight: | 22kDa, 173 residues |
| Immunogen: | peptide crosslinked to KLH |
| Cat. #: | 162215 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology |
| Application: | WB ; IHC |
| Target: | HSPB4 |
| Reactivity: | Human, rat |
| Class: | Polyclonal |
| Primary citation: | Sandilands A, et al. 2002. EMBO J. 15;21(22):6005-14. PMID: 12426373. |
| Target background: | HSPB4 is also known as Alpha-crystallin A chain, it is a lens crystallin. It contributes to the transparency and refractive index of the lens. Alpha crystallins can act as molecular chaperones. |
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| Format: | Liquid |
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| Concentration: | 1mg/ml |
| Storage buffer: | Serum plus azide (0.02%) |
| Storage conditions: | -80° C |
| Shipping conditions: | Dry ice |
| References: |
Naru J, et al. 2017. J Proteomics. 21 159:77-91. PMID: 28232133. Sandilands A, et al. 2002. EMBO J. 15 21(22):6005-14. PMID: 12426373. |
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