A monoclonal antibody for HSPB1p78 also known as HSP27p78.
| Inventor | Institute |
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| Roy Quinlan | University of Durham |
| SKU: | 162208 |
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| Product description: | A monoclonal antibody for HSPB1p78 also known as HSP27p78. This antibody targets HSPB1 (HSP27) a small heat shock protein which is involved in TP53 turnover, steroid receptor maturation, cytoskeletal dynamics, regulation of proteostasis and apoptosis. This antibody recognises HSPB1 when phosphorylated at serine 78. Phosphorylation of HSP27 can cause conformational changes in the tertiary structure resulting in decreased oligomeric size. |
| Alternate name: | HSPB1p78 ; HSP26p78 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Molecular weight: | 27kDa, 205 residues |
| Immunogen: | peptide crosslinked to KLH |
| Cat. #: | 162208 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology |
| Application: | WB ; IP ; IHC |
| Target: | human heat shock protein 27 phosphorylated at site 78, HSP27p78 |
| Reactivity: | Human |
| Clone: | 2.1 |
| Class: | Monoclonal |
| Primary citation: | P A Eyers, et al. 1999. FEBS Lett. 21;451(2):191-6. PMID: 10371163 |
| Target background: | Hsp27 is an ATP-independent molecular chaperone with well-described tumorigenic and metastatic roles, characterized by its dynamic phosphorylation leading to heterogeneous oligomerization under different conditions such as stress |
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| Format: | Liquid |
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| Concentration: | 1mg/ml |
| Storage buffer: | tissue culture media with cryoprotectant |
| Storage conditions: | liquid nitrogen |
| Shipping conditions: | Dry ice |
| References: |
Philip R Quinlan, et al. 2021. Cell Stress Chaperones. 27(2):177-188. PMID: 35235182. Alamgir M N Kabir, et al. 2005. J Mol Cell Cardiol. 39(4):709-17. PMID: 16140323 P A Eyers, et al. 1999. FEBS Lett. 21 451(2):191-6. PMID: 10371163 |
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