Anti-HPV16E7 [TVG 701Y] mAb

HPV early proteins E6 and E7 are the major viral oncoproteins that regulate cell proliferation through the inactivation of p53 and Rb1 tumour suppressor proteins respectively.

Contributors

Institute
University of Cambridge
Cat. #: 151170
Tool sub type: Primary antibody
Unit size: 100 ug
Cancer types: Cervical cancer
Research Fields: Cancer;Microbiology
Application: ELISA ; FACS ; IHC ; IF ; WB
Target: Human Papilloma Virus-16 early protein 7 (HPV16 E7)
Reactivity: Human papilloma virus
Clone: TVG 701Y
Host: Mouse
Class: Monoclonal
Primary citation: Tommasino et al. 1993. Oncogene. 8(1):195-202. PMID: 8380917.
Alternate name: Anti-Human Papillomavirus 16 (E7) antibody [TVG 701Y]; Anti-HPV16E7 [TVG 701Y]; HPV16 E7; Protein E7; E7; HPV antibody
Product description: Tumour antigens are proteins found in tumour cells and recognised by cellular or humoral effectors of the immune system. Tumour antigens are useful in identifying cancer cells, they also can be leveraged as targets in cancer therapy. Anti-Human Papillomavirus 16 (E7) antibody [TVG 701Y] also known as Anti-HPV16E7 [TVG 701Y] is an antibody against a tumour-specific antigen (TSA). TSA's are restricted to tumours and are not found in healthy cells. Anti-HPV16E7 [TVG 701Y] is a monoclonal antibody against HPV16E7. The human papilloma virus (HPV) family of DNA tumour viruses includes HPV-16 and HPV-18. These are associated with a large proportion of cervical cancer cases. E7 is the major transforming protein of human papillomavirus type 16 (HPV16). The immunogen is HPV 16 E7 synthesised from S. pombe.
Conjugation: Unconjugated
Isotype: IgG2a
Molecular weight: Antigen MW is 19KD
Immunogen: HPV 16 E7 synthesised from S. pombe
Myeloma used: P3/NS1/1-Ag4.1
Target background: The human papilloma virus (HPV) family of DNA tumor viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. HPV early proteins E6 and E7 are the major viral oncoproteins that regulate cell proliferation through the inactivation of p53 and Rb1 tumour suppressor proteins respectively.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: '-15° C to -25° C
Shipping conditions: Dry ice
References:

Chen et al. 2020. Antiviral Res. 178:104794. PMID: 32298665.

Kannan et al. 2017. Sci Rep. 7:46102. PMID: 28383029.

Harris et al. 2013. Br J Cancer. 108(4):859-865. PMID: 23385729.

Tommasino et al. 1993. Oncogene. 8(1):195-202. PMID: 8380917.

Images

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Detection of HPV-16-E7 expression. Adapted from Kannan et al. 2017.
Anti-HPV16E7 [TVG 701Y] mAb. Histopathological analysis of the normal and cancer tissues by haematoxylin and eosin staining. HPV-16-E7 protein was detected (arrowheads) by immunohistochemistry. Adapted from Kannan et al. 2017. Histopathological analysis of the normal and cancer tissues by haematoxylin and eosin staining. HPV-16-E7 protein was detected (arrowheads) by immunohistochemistry. Adapted from Kannan et al. 2017.

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