Anti-HPV-18 E6phospho

Nearly all cases of cervical cancer are associated with HPV infection, with two types, HPV16 and HPV18, present in 70% of cases.

Contributors

Inventor Institute
Lawrence Banks International Centre For Genetic Engineering And Biotechnology (ICGEB)
SKU: 153965
Product description: Nearly all cases of cervical cancer are associated with HPV infection, with two types, HPV16 and HPV18, present in 70% of cases. A defining feature of cervical cancers and derived cell lines is the continued expression of two viral oncoproteins, E6 and E7. A defining characteristic of E6 oncoproteins derived from cancer-causing HPV types is the presence of a PDZ binding motif (PBM) at the extreme carboxy terminus of the protein which is absent from E6 proteins derived from the so-called low-risk HPV types. Within this PBM is also a protein kinase A (PKA) phospho-acceptor site, which is thought to negatively regulate the association of E6 with its PDZ domain-containing substrates
Conjugation: Unconjugated
Immunogen: Peptide: RQERLQRRRETQV
Cat. #: 153965
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Microbiology
Application: WB
Target: HPV E6
Reactivity: Human papilloma virus
Host: Rabbit
Class: Polyclonal
Target background: Nearly all cases of cervical cancer are associated with HPV infection, with two types, HPV16 and HPV18, present in 70% of cases. A defining feature of cervical cancers and derived cell lines is the continued expression of two viral oncoproteins, E6 and E7. A defining characteristic of E6 oncoproteins derived from cancer-causing HPV types is the presence of a PDZ binding motif (PBM) at the extreme carboxy terminus of the protein which is absent from E6 proteins derived from the so-called low-risk HPV types. Within this PBM is also a protein kinase A (PKA) phospho-acceptor site, which is thought to negatively regulate the association of E6 with its PDZ domain-containing substrates
Format: Liquid
Storage buffer: Serum
Shipping conditions: Dry ice
References:

Boon et al. 2015. J Virol. 89(3):1579-86. PMID: 25410862.

Cancer-causing human papillomavirus E6 proteins display major differences in the phospho-regulation of their PDZ interactions.

Boon et al. 2013. J Virol. 87(3):1586-95. PMID: 23175360.

High-risk human papillomavirus E6 oncoproteins interact with 14-3-3 in a PDZ binding motif-dependent manner.

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