MoAb recognizes both HLA-G1 and the solube HLA-G5.
| Inventor | Institute |
|---|---|
| Daniel Geraghty | Fred Hutchinson Cancer Center |
| Cat. #: | 161666 |
|---|---|
| Tool sub type: | Primary antibody |
| Cancer types: | Skin cancer, Breast cancer |
| Research Fields: | Developmental biology;Immunology |
| Application: | FACS, IP(weak), ELISA, Histology. No western |
| Target: | HLA-G |
| Reactivity: | Human |
| Clone: | 87G |
| Host: | Mouse |
| Class: | Monoclonal |
| Primary citation: | lshitani et al.2003. Journal of lmmunology. 171(3):1376-84. PMID: 12874228 |
| Product description: | HLA-G has long been assumed a major factor in this immune accommodation because of its localized expression and because of low levels of allelic polymorphism. This MoAb was developed to examine the role of all three nonclassical class I Ags in the maternal immune response during pregnancy. MoAb 87G recognizes recognizes human HLA-G, a member of the Human Leukocyte Antigen family but as part of the nonclassical MHC type involved in inhibiting immune reponses. |
|---|---|
| Isotype: | IgG2a,? |
| Molecular weight: | The heavy chain is approximately 45 kDa |
| Target background: | HLA-G are expressed in the placenta, a membrane form and a soluble form, the latter containing an altered carboxyl terminu. HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (?2 microglobulin). The heavy chain is anchored in the membrane. |
|---|
| Storage buffer: | PBS, pH 7.2 |
|---|---|
| Storage conditions: | 4° C |
| Shipping conditions: | Dry ice |
| References: |
lshitani et al.2003.Journal of lmmunology. 171(3):1376-84.PMID: 12874228 Lee et al.1995. Immunity.(5):591-600.PMID: 7584149 |
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