Induction of the Hif regulated genes, as a consequence of the microenvironment or genetic changes, is known to have an important role in the growth of experimental tumours. HIF1A has been observed in varying subsets of tumour cells from various solid tumours.
| Inventor | Institute |
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| Helen Turley | University of Oxford |
| SKU: | 151198 |
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| Product description: | Induction of the Hif regulated genes, as a consequence of the microenvironment or genetic changes, is known to have an important role in the growth of experimental tumours. HIF1A has been observed in varying subsets of tumour cells from various solid tumours. |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Immunogen: | GST-human HIF1A amino acids 329-530 fusion protein |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Cat. #: | 151198 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer; Genetics |
| Application: | ELISA ; IHC ; WB |
| Target: | Hypoxia-inducible factor 1, alpha subunit (HIF1A) |
| Reactivity: | Human |
| Clone: | Ha111a |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Induction of the Hif regulated genes, as a consequence of the microenvironment or genetic changes, is known to have an important role in the growth of experimental tumours. HIF1A has been observed in varying subsets of tumour cells from various solid tumours. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Andr et al. 2008. J Biol Chem. 283(43):29375-84. PMID: 18694926. Identification of an alternative mechanism of degradation of the hypoxia-inducible factor-1alpha. Wiesener et al. 1998. Blood. 92(7):2260-8. PMID: 9746763. Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. |
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