Anti-hEMILIN2 [hEMIL2]

Emilin-2 (Elastin Microfibril Interface Located proteIN) is an extracellular matrix glycoprotein. Is part of a protein family which have been shown to be expressed in smooth muscle and other mesenchymal tissues and is localized at the proximity of elastin and microfibrils.

Contributors

Inventor Institute
Alfonso Colombatti ; Maurizio Mongiat ; Roberto Doliana ; Maria Teresa Mucignat National Cancer Institute CRO – Aviano
SKU: 160587
Product description: Emilin-2 (Elastin Microfibril Interface Located proteIN) is an extracellular matrix glycoprotein. Is part of a protein family which have been shown to be expressed in smooth muscle and other mesenchymal tissues and is localized at the proximity of elastin and microfibrils. Emilin-2 is larger than Emilin-1 and contains a unique proline-rich domain. It is involved in regulation of the extrinsic apoptotic pathway, by interacting with death receptors DR4 and DR5 and down-modulates the Wnt signalling pathway. EMILIN2 is also involved in the regulation of angiogenesis and elastogenesis
Conjugation: Unconjugated
Immunogen: Recombinant human Emilin-2 as immunizing antigen; BALB/c mice as host
Cat. #: 160587
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Apoptosis and autophagy; Cancer; Cell biology; Cell signaling and signal transduction
Application: ELISA ; IHC ; WB
Target: hEMILIN2
Reactivity: Human
Host: Mouse
Class: Monoclonal
Target background: Emilin-2 (Elastin Microfibril Interface Located proteIN) is an extracellular matrix glycoprotein. Is part of a protein family which have been shown to be expressed in smooth muscle and other mesenchymal tissues and is localized at the proximity of elastin and microfibrils. Emilin-2 is larger than Emilin-1 and contains a unique proline-rich domain. It is involved in regulation of the extrinsic apoptotic pathway, by interacting with death receptors DR4 and DR5 and down-modulates the Wnt signall…
Format: Liquid
Storage conditions: Store at 2 – 8° C or aliquots at -20° C. Avoid repeated freeze-thaw cycles
Shipping conditions: Dry ice
References:

Marastoni et al. 2014. J Pathol. 232(4):391-404. PMID: 24374807.

Mongiat et al. 2010. Neoplasia. 12(4):294-304. PMID: 20360940.

Mongiat et al. 2007. Mol Cell Biol. 27(20):7176-87. PMID: 17698584.

Images

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Human colon rectal tissue. Positive staining for EMILIN-2 (green). In blue nuclear staining. Scale bar

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