Anti-hEMILIN1 [hEMIL1]

It binds pro-TGF? preventing its maturation to mature TGF? in the extracellular space, therefore influencing the regulation of blood and lymph vessels formation and maintenance.

Contributors

Inventor Institute
Alfonso Colombatti ; Maurizio Mongiat ; Paola Spessotto ; Roberto Doliana ; Maria Teresa Mucignat National Cancer Institute CRO – Aviano
SKU: 160586
Product description: Emilin-1 (Elastin Microfibril Interface Located proteIN) is an extracellular matrix glycoprotein. It is part of a protein family which have been shown to be expressed in smooth muscle and other mesenchymal tissues and is localized at the proximity of elastin and microfibrils. Emilin-1 exerts an important role in lymphatic system, being a crucial structural molecule that regulates the formation of lymphatic capillaries and collectors. Emilin-1 through the interaction with the Î?4Î?1 integrin via the C-terminal gC1q domain exerts a negative effect on proliferation. It binds pro-TGFÎ? preventing its maturation to mature TGFÎ? in the extracellular space, therefore influencing the regulation of blood and lymph vessels formation and maintenance.
Conjugation: Unconjugated
Immunogen: Recombinant human Emilin-1 as immunizing antigen; Balb/c mice as host
Cat. #: 160586
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cell biology; Cell signaling and signal transduction
Application: ELISA ; IHC ; IF ; IP ; Fn ; WB
Target: hEMILIN1
Reactivity: Human
Host: Mouse
Class: Monoclonal
Target background: Emilin-1 (Elastin Microfibril Interface Located proteIN) is an extracellular matrix glycoprotein. It is part of a protein family which have been shown to be expressed in smooth muscle and other mesenchymal tissues and is localized at the proximity of elastin and microfibrils. Emilin-1 exerts an important role in lymphatic system, being a crucial structural molecule that regulates the formation of lymphatic capillaries and collectors. Emilin-1 through the interaction with the a4?1 integrin via…
Format: Liquid
Storage conditions: Store at 2 – 8° C or aliquots at -20° C. Avoid repeated freeze-thaw cycles
Shipping conditions: Dry ice
References:

Capuano et al. 2016. Hum Mutat. 37(1):84-97. PMID: 26462740.

Pivetta et al. 2014. Matrix Biol. 34:22-32. PMID: 24513040.

Danussi et al. 2013. Mol Cell Biol. 33(22):4381-94. PMID: 24019067.

Danussi et al. 2012. Cancer Prev Res (Phila). 5(9):1131-43. PMID: 22827975.

Danussi et al. 2011. J Cell Biol. 195(1):131-45. PMID: 21949412.

Danussi et al. 2008. Mol Cell Biol. 28(12):4026-39. PMID: 18411305.

Spessotto et al. 2006. J Cell Sci. 119(Pt 21):4574-84. PMID: 17074837.

Zacchigna et a…

Images

View Gallery
Schematic diagram depicting the epitope localization of three clones of anti EMILIN mAbs (from Spessotto et al.; 2003). Bottom; left

Related Tools for Antibodies

Cat. # Tool Name
151017 Anti-MBP [R29.6] Key Info View Tool
151029 Anti-HSVICP8 [11E2] Key Info View Tool
151023 Anti-IL12 [1-1D5] Key Info View Tool
151033 Anti-HSVUL42 [13C9] Key Info View Tool
151034 Anti-HSVUL42 [13D11] Key Info View Tool

Tool enquiry

Please ensure you use your organisation email address rather than personal where possible, as this helps us locate your organisation in our system faster.

Please note we may take up to three days to respond to your enquiry.

CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.