Anti-HDAC6-D1 (236) mouse (D1 domain-specific)

The enzyme deacetylates various substrates including a-tubulin, HSP90, cortactin, histones and other proteins. Described protein plays an important role in microtubule-dependent cell motility, apoptosis, cell signaling and transcriptional regulation, protein degradation, immune response and DNA repair.

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Institute
Institute of Biotechnology CAS
SKU: 157673
Product description: The affinity purified mouse monoclonal antibody is immunospecific for the D1 domain of human histone deacetylase 6 (HDAC6) as determined by ELISA and peptide library screening. Reactivity of the mAb to homologous proteins from other species has not been tested. HDAC6 belongs to the class II of the histone deacetylase family (EC 3.5.1.98). The protein of molecular mass 131 kDa consists of two catalytic domains, the serine-glutamate-rich SE14 domain and the ubiquitin-binding ZnF domain. HDAC6 shuttles between the nucleus and the cytoplasm, but its localization is predominantly cytoplasmic. The enzyme deacetylates various substrates including Î?-tubulin, HSP90, cortactin, histones and other proteins. Described protein plays an important role in microtubule-dependent cell motility, apoptosis, cell signaling and transcriptional regulation, protein degradation, immune response and DNA repair. HDAC6 is linked to several neuronal diseases and carcinogenesis.
Alternate name: Histone deacetylase 6; HD6
Conjugation: Unconjugated
Isotype: IgG
Immunogen: human histone deacetylase 6 (HDAC6; sequence NP_006035.2)
Immunogen Uniprot ID: Q9UBN7
Cat. #: 157673
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cell biology; Genetics
Application: ELISA ; IHC ; IP ; WB
Target: epitope in D1 domain of human histone deacetylase 6
Reactivity: Human
Host: Mouse
Class: Monoclonal
Target background: The affinity purified mouse monoclonal antibody is immunospecific for the D1 domain of human histone deacetylase 6 (HDAC6) as determined by ELISA and peptide library screening. Reactivity of the mAb to homologous proteins from other species has not been tested. HDAC6 belongs to the class II of the histone deacetylase family (EC 3.5.1.98). The protein of molecular mass 131 kDa consists of two catalytic domains, the serine-glutamate-rich SE14 domain and the ubiquitin-binding ZnF domain. HDAC6 s…
Format: Liquid
Shipping conditions: Dry ice

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