Anti-GTP [2A4]

Ras GTPases are frequently mutated in cancer and so far only few experimental inhibitors exist.

Contributors

Inventor Institute
Urpo Lamminmäki University of Turku
SKU: 157718
Product description: GTPases are central cellular signaling proteins, which cycle between a GDP-bound inactive and a GTP-bound active conformation in a controlled manner. Ras GTPases are frequently mutated in cancer and so far only few experimental inhibitors exist. The most common methods for monitoring GTP hydrolysis rely on luminescent GDP- or GTP-analogs. (From Kopra et al Anal. Chem. 2015)
Conjugation: Unconjugated
Cat. #: 157718
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer; Metabolism
Application: ELISA ; FACS ; IF
Target: GTP
Reactivity: Human
Class: Recombinant
Target background: GTPases are central cellular signaling proteins, which cycle between a GDP-bound inactive and a GTP-bound active conformation in a controlled manner. Ras GTPases are frequently mutated in cancer and so far only few experimental inhibitors exist. The most common methods for monitoring GTP hydrolysis rely on luminescent GDP- or GTP-analogs. (From Kopra et al Anal. Chem. 2015, 87, 6, 35273534)
Format: Liquid
Shipping conditions: Dry ice
References:

Kopra et al. 2017. Anal Chem. 89(8):4508-4516. PMID: 28318223.

Kopra et al. 2015. Anal Chem. 87(6):3527-34. PMID: 25707436.

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