The Golgi complex is an intricate cytoplasmic organelle that has a major function in the processing, transporting, and sorting of intracellular proteins following synthesis in the rough endoplasmic reticulum. Golgins are Golgi-localized proteins with extensive coiled-coil structure throughout the entire polypeptide which serve as tethering molecules or matrix proteins for the cisternal architecture of Golgi apparatus. Glogins belonging to the Glutamate receptor-interacting protein (GRIP) family are targeted to the trans-face of the Golgi by their C-terminal GRIP domains and play an essential role as tethering molecules for tubulovesicular carriers of the trans-Golgi Network (TGN).Golgin-97 resides on the cytoplasmic face of…
| Inventor | Institute |
|---|---|
| Martin Fritzler | University of Calgary |
| SKU: | 157877 |
|---|---|
| Product description: | The Golgi complex is an intricate cytoplasmic organelle that has a major function in the processing, transporting, and sorting of intracellular proteins following synthesis in the rough endoplasmic reticulum. Golgins are Golgi-localized proteins with extensive coiled-coil structure throughout the entire polypeptide which serve as tethering molecules or matrix proteins for the cisternal architecture of Golgi apparatus. Glogins belonging to the Glutamate receptor-interacting protein (GRIP) family are targeted to the trans-face of the Golgi by their C-terminal GRIP domains and play an essential role as tethering molecules for tubulovesicular carriers of the trans-Golgi Network (TGN).Golgin-97 resides on the cytoplasmic face of the Golgi and plays an essential role as tethering molecules on the TGN for retrograde traffic from the early and/or recycling endosomes. As a GRIP family member, Golgin-97 maintains cell polarity. Binding to the Golgi membrane is mediated by the G protein family member Arl1, and this pathway is a key regulatory process for endosomeÄËĂÂĂÂTGN traffic. |
| Alternate name: | Golgin subfamily A member 1 |
| Conjugation: | Unconjugated |
| Molecular weight: | 88 |
| Cat. #: | 157877 |
|---|---|
| Unit size: | 100 ug |
| Research Fields: | Cell biology |
| Application: | IF ; WB |
| Target: | Golgin 97 |
| Reactivity: | Human ; Rabbit |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | The Golgi complex is an intricate cytoplasmic organelle that has a major function in the processing, transporting, and sorting of intracellular proteins following synthesis in the rough endoplasmic reticulum. Golgins are Golgi-localized proteins with extensive coiled-coil structure throughout the entire polypeptide which serve as tethering molecules or matrix proteins for the cisternal architecture of Golgi apparatus. Glogins belonging to the Glutamate receptor-interacting protein (GRIP) family are targeted to the trans-face of the Golgi by their C-terminal GRIP domains and play an essential role as tethering molecules for tubulovesicular carriers of the trans-Golgi Network (TGN).Golgin-97 resides on the cytoplasmic face of the Golgi and plays an essential role as tethering molecules on the TGN for retrograde traffic from the early and/or recycling endosomes. As a GRIP family member, Golgin-97 maintains cell polarity. Binding to the Golgi membrane is mediated by the G protein family member Arl1, and this pathway is a key regulatory process for endosomeÄËĂÂĂÂTGN traffic. |
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| Format: | Liquid |
|---|---|
| Shipping conditions: | Dry ice |
| References: |
Nozawa et al. 2009. Cell Biol Int. 33(2):148-57. PMID: 19000931. |
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