This is a site specific polyclonal antibody, recognising a domain that is key to the assembly of GFAP. The site is contained within exon 9, and therefore allows the identification of GFAP splice variants (Buniatian GH et al). Glial fibrillary acidic protein-positive cells of the kidney are capable of raising a protective biochemical barrier similar to astrocytes: expression of metallothionein in podocytes (de Reus AJEM et al 2024).
| Inventor | Institute |
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| Roy Quinlan | University of Durham |
| SKU: | 162213 |
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| Product description: | This is a site specific polyclonal antibody, recognising a domain that is key to the assembly of GFAP. The site is contained within exon 9, and therefore allows the identification of GFAP splice variants (Buniatian GH et al). Glial fibrillary acidic protein-positive cells of the kidney are capable of raising a protective biochemical barrier similar to astrocytes: expression of metallothionein in podocytes (de Reus AJEM et al 2024). |
| Alternate name: | GFAP |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Molecular weight: | 51kDa, 432 residues |
| Immunogen: | peptide crosslinked to KLH |
| Cat. #: | 162213 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology |
| Application: | WB ; IP ; IHC |
| Target: | glial fibrillary acidic protein GFAP |
| Reactivity: | Human |
| Class: | Polyclonal |
| Primary citation: | Der Perng M, et al. 2006. Am J Hum Genet. 79(2):197-213. PMID: 16826512. |
| Target background: | GFAP is an intermediate filament that is expressed in astrocytes. Intermediate filaments are a distinct group of cytoskeletal molecules. |
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| Format: | Liquid |
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| Concentration: | 1mg/ml |
| Storage buffer: | Serum plus azide (0.02%) |
| Storage conditions: | -80° C |
| Shipping conditions: | Dry ice |
| References: |
Naru J, et al. 2017. J Proteomics. 21 159:77-91. PMID: 28232133. |
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