Anti-FBW7 [FBOX 3a9/1]

FBW7 is a tumor suppressor that is mutated in a wide spectrum of human cancers, and FBW7 functions as a haplo-insufficient tumor suppressor in mice.

Contributors

Institute
Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Cat. #: 151461
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Biochemistry;Cancer
Application: FACS ; IHC ; IF ; IP ; WB
Target: F-box/WD repeat-containing protein 7 (FBW7, Cdc4)
Reactivity: Human ; Mouse
Clone: FBOX 3a9/1
Host: Mouse
Class: Monoclonal
Alternate name: F-Box And WD Repeat Domain Containing 7; F-Box Protein FBX3; SEL-1; Fbx3; HCdc4; FBW7; Hago; Homolog Of C Elegans Sel-1; F-Box Protein SEL-1; Archipelago Homolog; F-Box Protein FBW7; Archipelago; FBXO3; FBXW6; CDC4; FBW6; AGO
Product description: SCF (Skp, Cullin, F-box containing complex) ubiquitin ligases regulate the degradation of many proteins involved in the control of cell division and growth. F-box proteins are the SCF components that bind to substrates, and this binding is usually signaled by substrate phosphorylation. The FBW7/Cdc4 F-box protein was first recognized by its ability to bind cyclin E, and the SCF (FBW7) is now known to target c-Myc, c-Jun and Notch for degradation in addition to its role in cyclin E proteolysis. FBW7 thus negatively regulates several key oncoproteins. Accordingly, FBW7 is a tumor suppressor that is mutated in a wide spectrum of human cancers, and FBW7 functions as a haplo-insufficient tumor suppressor in mice.
Conjugation: Unconjugated
Isotype: IgG1
Immunogen: Synthetic peptide of human sequence
Myeloma used: Sp2/0-Ag14
Target background: SCF (Skp, Cullin, F-box containing complex) ubiquitin ligases regulate the degradation of many proteins involved in the control of cell division and growth. F-box proteins are the SCF components that bind to substrates, and this binding is usually signaled by substrate phosphorylation. The FBW7/Cdc4 F-box protein was first recognized by its ability to bind cyclin E, and the SCF (FBW7) is now known to target c-Myc, c-Jun and Notch for degradation in addition to its role in cyclin E proteolysis. FBW7 thus negatively regulates several key oncoproteins. Accordingly, FBW7 is a tumor suppressor that is mutated in a wide spectrum of human cancers, and FBW7 functions as a haplo-insufficient tumor suppressor in mice.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Tu et al. 2013. PLoS One. 8(7):e68574. PMID: 23840897.

Recombinant human adenovirus-p53 injection induced apoptosis in hepatocellular carcinoma cell lines mediated by p53-Fbxw7 pathway, which controls c-Myc and cyclin E.

Nateri et al. 2004. Science. 303(5662):1374-8. PMID: 14739463.

The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling.

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Adapted from Tu et al. 2013. PLoS One. 8(7)

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