Anti-ERCC1 [ERCC1 3H11]

Nucleotide excision repair (NER) is a DNA repair pathway that removes lesions induced by a variety of agents such as UV irradiation. ERCC1 binds to XPF to form the heterodimer ERCC1-XPF, which is a DNA endonuclease that is essential for the dual incision step of NER (cleaves 5′ of the DNA lesion). Some publications report that ERCC1 is elevated in cisplatin-resistant cells.

Contributors

Inventor Institute
Julian Gannon Cancer Research UK, London Research Institute: Lincoln's Inn Fields
SKU: 151050
Product description: Nucleotide excision repair (NER) is a DNA repair pathway that removes lesions induced by a variety of agents such as UV irradiation. ERCC1 binds to XPF to form the heterodimer ERCC1-XPF, which is a DNA endonuclease that is essential for the dual incision step of NER (cleaves 5′ of the DNA lesion). Some publications report that ERCC1 is elevated in cisplatin-resistant cells.
Alternate name: Cyclin-Dependent Kinase 1; Cell Division Cycle 2, G1 To S And G2 To M; Cell Division Control Protein 2 Homolog; Cell Division Protein Kinase 1; P34 Protein Kinase; P34CDC2; CDC28A; CDC2; Cell Cycle Controller CDC2; CDKN1
Conjugation: Unconjugated
Isotype: IgG2a
Molecular weight: 33-36
Immunogen: Full length HIS-tagged recombinant human ERCC1
Myeloma used: Sp2/0-Ag14
Cat. #: 151050
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer;Genetics
Application: IF ; IP ; WB
Target: ERCC1
Reactivity: Human
Clone: ERCC1 3H11
Host: Mouse
Class: Monoclonal
Target background: Nucleotide excision repair (NER) is a DNA repair pathway that removes lesions induced by a variety of agents such as UV irradiation. ERCC1 binds to XPF to form the heterodimer ERCC1-XPF, which is a DNA endonuclease that is essential for the dual incision step of NER (cleaves 5′ of the DNA lesion). Some publications report that ERCC1 is elevated in cisplatin-resistant cells.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

HCMV-infected cells maintain efficient nucleotide excision repair of the viral genome while abrogating repair of the host genome.

O'Dowd et al. 2012. PLoS Pathog. 8(11):e1003038. PMID: 23209410.

Bhagwat et al. 2009. Cancer Res. 69(17):6831-8. PMID: 19723666.

Immunodetection of DNA repair endonuclease ERCC1-XPF in human tissue.

Biggerstaff et al. 1993. EMBO J. 12(9):3685-92. PMID: 8253090.

Co-correction of the ERCC1, ERCC4 and xeroderma pigmentosum group F DNA repair defects in vitro.

Images

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Adapted from O'Dowd et al. 2012. PLoS Pathog. 8(11)

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