Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane.
| Inventor | Institute |
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| Chris Dean | The Institute of Cancer Research |
| SKU: | 153390 |
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| Product description: | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. |
| Alternate name: | ERBB2; Tyrosine kinase type cell surface receptor HER2 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2b |
| Molecular weight: | 77 kDa |
| Immunogen: | Paper not available |
| Cat. #: | 153390 |
|---|---|
| Provenance and Ownership: | The Anti-ErbB2 [ICR52] is owned by Cancer Research UK. CancerTools supplies the Anti-ErbB2 [ICR52] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-ErbB2 [ICR52] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer; Cell biology; Cell signaling and signal transduction |
| Application: | IHC |
| Target: | Erb-B2 |
| Reactivity: | Human |
| Clone: | ICR52 |
| Host: | Rat |
| Class: | Monoclonal |
| Target background: | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. |
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| Format: | Liquid |
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| Shipping conditions: | Dry ice |
| References: |
Styles et al. 1990. Int J Cancer. 45(2):320-4. PMID: 1689275. Rat monoclonal antibodies to the external domain of the product of the C-erbB-2 proto-oncogene. |
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