This enzyme has been localized to the endoplasmic reticulum in primary endothelial cells, but colocalizes with nucleoli in the nuclei of breast, colon, and renal cancer cells.
| Inventor | Institute |
|---|---|
| Roy Bicknell | University of Oxford |
| Cat. #: | 151624 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Apoptosis and autophagy;Cancer;Cell signaling and signal transduction |
| Application: | ELISA ; IHC ; IF ; IP ; WB |
| Target: | EndoPDI |
| Reactivity: | Human |
| Clone: | 2E7/7 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Endothelial protein disulfide isomerase (EndoPDI; TXNDC5) is a thioredoxin member of the protein disulfide isomerase family of chaperone proteins. This enzyme has been localized to the endoplasmic reticulum in primary endothelial cells, but colocalizes with nucleoli in the nuclei of breast, colon, and renal cancer cells. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Immunogen: | Synthesized peptide – 12 amino acids long (ADGEDGQDPHSK) corresponding to residues 52 – 63 of the EndoPDI protein. |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Endothelial protein disulfide isomerase (EndoPDI; TXNDC5) is a thioredoxin member of the protein disulfide isomerase family of chaperone proteins. This enzyme has been localized to the endoplasmic reticulum in primary endothelial cells, but colocalizes with nucleoli in the nuclei of breast, colon, and renal cancer cells. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Sullivan et al. 2003. J Biol Chem. 278(47):47079-88. PMID: 12963716. EndoPDI, a novel protein-disulfide isomerase-like protein that is preferentially expressed in endothelial cells acts as a stress survival factor. |
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