Anti-ELOVL5 [Z88]

This protein is involved in the elongation of long-chain polyunsaturated fatty acids functioning as a condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA

Contributors

Inventor Institute
Ayham Alnabulsi Vertebrate Antibodies Limited
Cat. #: 153343
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cell signaling and signal transduction;Tissue-specific biology
Application: ELISA ; IHC ; WB
Target: ELOVL Fatty Acid Elongase 5
Reactivity: Human
Clone: Z88
Host: Mouse
Class: Monoclonal
Alternate name: Elongation of very long chain fatty acids protein 5; ELOVL5; 3-keto acyl-CoA synthase ELOVL5; ELOVL FA elongase 5; Fatty acid elongase 1; Very long chain 3-ketoacyl-CoA synthase 5
Product description: This protein is involved in the elongation of long-chain polyunsaturated fatty acids functioning as a condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. It may also participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. It is highly expressed in the adrenal gland and testis, and encodes a multi-pass membrane protein that is localized in the endoplasmic reticulum.
Conjugation: Unconjugated
Isotype: IgG
Immunogen: Peptide Sequence NNVKPRKLR (peptide immunogen is identical in primates)
Myeloma used: P3X63Ag8.653
Target background: This protein is involved in the elongation of long-chain polyunsaturated fatty acids functioning as a condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. It may also participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. It is highly expressed in the adrenal gland and testis, and encodes a multi-pass membrane protein that is localized in the endoplasmic reticulum.
Format: Liquid
Concentration: 0.9-1.1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

The expression of brown fat-associated proteins in colorectal cancer and the relationship of uncoupling protein 1 with prognosis.

The expression of brown fat associated proteins in colorectal cancer and the relationship of uncoupling protein 1 with prognosis. Alnabulsi et al. 2019. Int J Cancer. :. PMID: 30737786.

Images

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Immunohistochemistry images are showing a strong cytoplasmic positivity of ELOVL5 in (A) primary colorectal cancer whilst weak staining is observed in (B) normal colon mucosa using Anti-ELOVL5 [Z88]. IHC was performed on formalin-fixed; paraffin-embedded tissue sections. Antigen retrieval step is required (microwave 10 min @ 950W in 0.01M sodium citrate buffer; pH 6.0).

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