This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor.
| Inventor | Institute |
|---|---|
| Chris Dean | The Institute of Cancer Research |
| SKU: | 153387 |
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| Product description: | The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. |
| Alternate name: | ERBB1; HER1; epidermal growth factor receptor; ERBB; mENA; PIG61 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Molecular weight: | 42.4 kDa |
| Immunogen: | Squamous cell carcinoma |
| Cat. #: | 153387 |
|---|---|
| Provenance and Ownership: | The Anti-EGFR [ICR11] is owned by Cancer Research UK. CancerTools supplies the Anti-EGFR [ICR11] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-EGFR [ICR11] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer; Cell signaling and signal transduction |
| Application: | FACS ; IHC ; IP |
| Target: | EGFR |
| Reactivity: | Human |
| Clone: | ICR11 |
| Host: | Rat |
| Class: | Monoclonal |
| Target background: | The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. |
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| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
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