Autoantibodies directed against the 160 kDa EEA1 protein are seen in patients diagnosed with neurological and autoimmune conditions
| Inventor | Institute |
|---|---|
| Martin Fritzler | University of Calgary |
| Cat. #: | 157879 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology |
| Application: | IF ; WB |
| Target: | EEA1 (Early endosome antigen) |
| Reactivity: | Human ; Rabbit |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | MST15; MSTP15; ZFYVE2; early endosome antigen 1; early endosome antigen 1, 162kD; early endosome-associated protein; Endosome-associated protein p162; MSTP15; ZFYVE2; ZFYVE2MST15; Zinc finger FYVE domain-containing protein 2 |
|---|---|
| Product description: | Endosomes are cytoplasmic membrane-bound vesicles that function in the sorting and delivery of internalized material from the cell surface and the transport of materials from the golgi. Formed via endocytosis, endosomes can be classified by their gross morphology: early endosomes are composed of dynamic tubules whereas late endosomes are spherical with multiple internal vesicles. In neurons, early endosomes are involved in recycling of synaptic vesicles and neurotransmitter receptors. Early endosome antigen 1 (EEA1), a peripheral membrane protein associated with the cytoplasmic face of early endosomes, controls vesicle fusion during endocytosis. EEA1 is involved in neuronal synaptic vesicle function and axonal transport and growth. Autoantibodies directed against the 160 kDa EEA1 protein are seen in patients diagnosed with neurological and autoimmune conditions |
| Conjugation: | Unconjugated |
| Molecular weight: | 162 kDa |
| Immunogen: | Recombinant protein |
| Target background: | Endosomes are cytoplasmic membrane-bound vesicles that function in the sorting and delivery of internalized material from the cell surface and the transport of materials from the golgi. Formed via endocytosis, endosomes can be classified by their gross morphology: early endosomes are composed of dynamic tubules whereas late endosomes are spherical with multiple internal vesicles. In neurons, early endosomes are involved in recycling of synaptic vesicles and neurotransmitter receptors. Early… |
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| Format: | Liquid |
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| Shipping conditions: | Dry ice |
| References: |
Selak et al. 2006. Neuroscience. 143(4):953-64. PMID: 17113235. Selak et al. 2004. Biochem Biophys Res Commun. 323(4):1334-42. PMID: 15451443. Selak et al. 2004. BMC Neurosci. 5:2. PMID: 14728723. Selak et al. 2003. Clin Immunol. 109(2):154-64. PMID: 14597214. |
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