It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signalling pathways.
| Institute |
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| Netherlands Cancer Institute |
| SKU: | 154777 |
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| Product description: | Diacylglycerol kinase alpha is an enzyme that belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signalling pathways. It also plays an important role in the resynthesise of phosphatidylinositol’s and phosphorylating diacylglycerol to phosphatidic acid. |
| Alternate name: | DGKA; Diacylglycerol Kinase Alpha |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Molecular weight: | 77 kDa |
| Immunogen: | Immunized with an Escherichia coli cell-expressed, affinity-purified glutathione S-transferase protein of a C-terminal portion (part of the Catalytic domain) of Rat DGKu. |
| Myeloma used: | Sp2/0-Ag14 |
| Cat. #: | 154777 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell signaling and signal transduction; Immunology; Metabolism |
| Application: | IP ; WB |
| Target: | DGKa |
| Reactivity: | Human |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Diacylglycerol kinase alpha is an enzyme that belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signalling pathways. It also plays an important role in the resynthesise of phosphatidylinositol’s and phosphorylating diacylglycerol to phosphatidic acid. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Schaap et al. 1993. Biochem J. 289 ( Pt 3):875-81. PMID: 7679574. |
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