| Inventor | Institute |
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| David Garrod | University of Southampton |
| SKU: | 151720 |
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| Product description: | Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Desmosomes are intercellular adhesive junctions that occur in almost all epithelia and should therefore be useful as epithelial markers in tumour diagnosis. This antibody was tested for its ability to stain epithelia and tumours. 32-2B is a reliable epithelial marker that may have a useful role in diagnostic histopathology. |
| Alternate name: | Cadherin family member 4, CDHF4, Desmoglein-1, Desmosomal glycoprotein 1, DG1, DGI, DSG, DSG1, EPKHE, EPKHIA, Pemphigus foliaceus antigen, PPKS1, SPPK1 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a kappa |
| Immunogen: | Bovine desmoglein (desmosomal glycoprotein I) from nasal epidermis |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Cat. #: | 151720 |
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| Provenance and Ownership: | The Anti-Desmoglein 1 [32-2B] is owned by Cancer Research UK. CancerTools supplies the Anti-Desmoglein 1 [32-2B] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-Desmoglein 1 [32-2B] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer; Cell biology; Cell signaling and signal transduction |
| Application: | EM (EM) ; IHC ; IF ; WB |
| Target: | Desmoglein 1 |
| Reactivity: | Bovine ; Human |
| Clone: | 32-2B |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Desmosomes are intercellular adhesive junctions that occur in almost all epithelia and should therefore be useful as epithelial markers in tumour diagnosis. This antibody was tested for its ability to stain epithelia and tumours. 32-2B is a reliable epithelial marker that may have a useful role in diagnostic histopathology. |
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| Format: | Liquid |
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| Concentration: | 1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Maruani et al. 2008. Am J Clin Pathol. 130(3):369-74. PMID: 18701409. Immunostaining with antibodies to desmoglein provides the diagnosis of drug-induced pemphigus and allows prediction of outcome. A simple epithelial cell line (MDCK) shows heterogeneity of desmoglein isoforms, one resembling pemphigus vulgaris antigen. Vilela et al. 1995. J Cell Sci. 108 ( Pt 4):1743-50. PMID: 7615689. Harada et al. 1992. Int J Oral Maxillofac Surg. 21(6):346-9. PMID: 1282923. Immunohistochemical detection of desmosomes in oral squamous cell carcinomas: correlation with differentiation, mode of invasion, and metastatic potential. Conn et al. 1990. Br J Urol. 65(2):176-80. PMID: 2317652. Immunohistochemical staining with monoclonal antibody 32-2B to desmosomal glycoprotein 1. Its role in the histological assessment of urothelial carcinomas. Vilela et al. 1987. J Pathol. 153(4):365-75. PMID: 3323436. Monoclonal antibody to desmosomal glycoprotein 1–a new epithelial marker for diagnostic pathology. |
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