An anti-deltaN isoform of p63 mouse monoclonal IgG1 antibody
| Institute |
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| Moravian Biotechnology |
| SKU: | 162059 |
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| Product description: | Antibody created to detect the deltaN isoform of p63 (deltaNp63) with tumour suppressor role and differentiate from the TA (TAp63) isoforms of the same protein. Binding specificity: Epitope mapping using phage display identified the epitope PSHLIR, which occurs twice within the central region of p63. The antibody recognizes TAp63 and deltaNp63. The antibody does not cross-react with p53 or any p73 isoform tested. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Molecular weight: | 72-76 kDa (variable, depending on the p63 isoform present) |
| Immunogen: | PSHLIR sequence of tumour protein p63 (deltaN isoform) |
| Cat. #: | 162059 |
|---|---|
| Tool sub type: | Primary antibody |
| Target: | tumour protein p63 lacking the transactivation domain (TA) |
| Reactivity: | Human ; mouse ; rat |
| Clone: | PANp63-6.1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | p63 is a transcription factor of the p53 gene family, encoded by the TP63 gene located at chromosome 3q28. p63 exists as N-terminal isoforms that either contain (TAp63) or lack (deltaNp63) the p53-like transactivation domain at the N-terminus. C-terminal isoforms are produced by alternative splicing of 3′ exons. TAp63 is involved in germ cell maintenance and myocyte differentiation, and is expressed in some lymphocytes and lymphomas/leukemias. |
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| Format: | Liquid |
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| Shipping conditions: | Dry ice |
| References: |
Nekulova et al. 2013. Virchows Arch. Sep:463(3):415-25. PMID: 23887585 Liu et al. 2020. J Pathol Clin Res. Jan:6(1):83-93. PMID: 31591823 Galoczova et al. 2021. Virchows Arch. Apr:478(4):627-636. PMID: 33037932 Stenckova et al. 2023. Neoplasma Oct:70(5):621-632. PMID: 38053383 |
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