An anti-delta Np63 mouse monoclonal IgG1 antibody
| Institute |
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| Moravian Biotechnology |
| Cat. #: | 162058 |
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| Tool sub type: | Primary antibody |
| Research Fields: | Cell signaling and signal transduction |
| Target: | tumour protein p63 lacking the transactivation domain (TA) |
| Reactivity: | Human ; mouse ; rat |
| Clone: | deltaNp63-1.1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Antibody created to detect the deltaN isoform of p63 (deltaNp63) with tumour suppressor role and differentiate from the TA (TAp63) isoforms of the same protein. Binding specificity: within MLYLENNAQTQFSE. No cross-reaction with p53 or p73 isoforms. Specificity verified by CRISPR-knockout and shRNA knockdown. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Molecular weight: | 72 kDa |
| Immunogen: | peptide MLYLENNAQTQFSE of tumour protein p63 (deltaN isoform) coupled to keyhole limpet hemocyanin |
| Target background: | p63 is a transcription factor of the p53 gene family, encoded by the TP63 gene located at chromosome 3q28. p63 exists as N-terminal isoforms that either contain (TAp63) or lack (deltaNp63) the p53-like transactivation domain at the N-terminus. C-terminal isoforms are produced by alternative splicing of 3' exons. TAp63 is involved in germ cell maintenance and myocyte differentiation, and is expressed in some lymphocytes and lymphomas/leukemias. |
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| Format: | Liquid |
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| Shipping conditions: | Dry ice |
| References: |
Orzol et al. 2016. Tumour Biol. Aug:37(8):10133-40. PMID: 26825981 Galoczova et al. 2021. Virchows Arch. Apr:478(4):627-636. PMID: 33037932 Pokorna et al. 2022. Front Oncol. Jul 14:12:924354. PMID: 35912168 |
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