Cytokeratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family.
| Inventor | Institute |
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| Arnoud Sonnenberg | Netherlands Cancer Institute |
| SKU: | 154746 |
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| Product description: | Cytokeratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene |
| Alternate name: | KRT18; Keratin 18 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 48 kDa |
| Immunogen: | Cytoskeletal preperation extracted from humen epidermis |
| Myeloma used: | Sp2/0-Ag14 |
| Cat. #: | 154746 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer; Cell biology |
| Application: | FACS ; IHC ; IF ; IP ; WB |
| Target: | Cytokeratin 18 |
| Reactivity: | Dog ; Human ; Feline |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Cytokeratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Glebov et al. 2006. Nat Cell Biol. 8(1):46-54. PMID: 16341206. Bonfrer et al. 1994. Tumour Biol. 15(4):210-22. PMID: 7524130. Vos et al. 1992. Zentralbl Veterinarmed A. 39(10):721-40. PMID: 1283472. |
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