Anti-Cytochrome P450 4F11 [F21 P6 F5]

Contributors

Inventor Institute
Ayham Alnabulsi Vertebrate Antibodies Limited
SKU: 151865
Product description: Cytochrome P450 4F11 (CYP4F11) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. Cytochromes P450 catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP4F11 has catalytic properties towards endogenous eicosanoids as well as some clinically relevant drugs, including benzphetamine, ethylmorphine, chlorpromazine, imipramine and erythromycin. CYP4F11 is expressed in the liver, kidney, heart, brain, and skeletal muscle and is overexpressed in ovarian and colon cancers.
Conjugation: Unconjugated
Isotype: IgG1 kappa
Immunogen: Ovalbumin-conjugated synthetic peptide RVEPLGANSQ (C-terminal sequence)
Cat. #: 151865
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer; Cell signaling and signal transduction; Metabolism; Tissue-specific biology
Application: ELISA ; IHC ; WB
Target: CYP4F11- Cytochrome P450 4F11 (EC 1.14.14.1) (CYPIVF11)
Reactivity: Human
Clone: F21 P6 F5
Host: Mouse
Class: Monoclonal
Target background: Cytochrome P450 4F11 (CYP4F11) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. Cytochromes P450 catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP4F11 has catalytic properties towards endogenous eicosanoids as well as some clinically relevant drugs, including benzphetamine, ethylmorphine, chlorpromazine, imipramine and erythromycin. CYP4F11 is expressed in the liver, kidney, heart, brain, and skeletal muscle and is overexpressed in ovarian and colon cancers.
Format: Liquid
Concentration: 0.9-1.1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Alnabulsi et al. 2017. Br J Cancer. :. PMID: 28557975.

The differential expression of omega-3 and omega-6 fatty acid metabolising enzymes in colorectal cancer and its prognostic significance.

Alnabulsi et al. 2016. Characterisation of Arachidonic Acid Metabolising Enzymes in Colorectal Cancer. J Pathol. 240 Suppl 1:S1-S48. PMID: 27747872

Nottingham Pathology 2016. 9th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 28 June – 1 July 2016.

Downie et al. 2005. Clin Cancer Res. 11(20):7369-75. PMID: 16243809.

Profiling cytochrome P450 expression in ovarian cancer: identification of prognostic markers.

Kumarakulasingham et al. 2005. Clin Cancer Res. 11(10):3758-65. PMID: 15897573.

Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis.

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Western Blot of cell lysates

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