This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.
| Inventor | Institute |
|---|---|
| Roland Wolf | University of Dundee |
| SKU: | 151725 |
|---|---|
| Product description: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. |
| Conjugation: | Unconjugated |
| Immunogen: | Purified recombinant human P450s |
| Cat. #: | 151725 |
|---|---|
| Provenance and Ownership: | The Anti-Cytochrome P450 2E1 [CYP2E1] is owned by Cancer Research UK. CancerTools supplies the Anti-Cytochrome P450 2E1 [CYP2E1] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-Cytochrome P450 2E1 [CYP2E1] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer; Cell signaling and signal transduction; Genetics; Metabolism; Tissue-specific biology |
| Application: | WB |
| Target: | Cytochrome P450 2E1, CYP2E1 |
| Reactivity: | Human |
| Clone: | CYP2E1 |
| Host: | Sheep |
| Class: | Polyclonal |
| Target background: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. |
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| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
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