Cyclin E is a member of the cyclin family of proteins, which regulates the cell cycle through its activation of cyclin-dependent kinases.
| Inventor | Institute |
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| Edward Kipreos | University of Georgia |
| SKU: | 153927 |
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| Product description: | Cyclin E is a member of the cyclin family of proteins, which regulates the cell cycle through its activation of cyclin-dependent kinases. Specifically, cyclin E binds and activates the S phase Cdk2. The cyclin EÄËĂÂĂÂCdk2 complex promotes the G1 to S phase cell cycle transition. Overexpression of cyclin E has been implicated in carcinomas among the gastrointestinal tract, including colon or stomach cancer as well as a marker for breast cancers |
| Alternate name: | CYE-1 |
| Conjugation: | Unconjugated |
| Immunogen: | Full-length recombinant CYE-1 protein |
| Cat. #: | 153927 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology |
| Application: | WB ; IF |
| Target: | Cyclin E |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Cyclin E is a member of the cyclin family of proteins, which regulates the cell cycle through its activation of cyclin-dependent kinases. Specifically, cyclin E binds and activates the S phase Cdk2. The cyclin ECdk2 complex promotes the G1 to S phase cell cycle transition. Overexpression of cyclin E has been implicated in carcinomas among the gastrointestinal tract, including colon or stomach cancer as well as a marker for breast cancers |
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| Format: | Liquid |
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| Shipping conditions: | Dry ice |
| References: |
Kim et al. 2007. Mol Cell Biol. 27(4):1394-406. PMID: 17145765. The Caenorhabditis elegans replication licensing factor CDT-1 is targeted for degradation by the CUL-4/DDB-1 complex. |
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