Monoclonal antibody raised against sequence of c-Myc, a proto-oncogene heavily implicated in a variety of (hematopoietic) cancers, which has been used in cancer research to detect and understand the distribution of the c-Myc oncogene product.
| Inventor | Institute |
|---|---|
| Gerard Evan | University of California San Francisco |
| Cat. #: | 151067 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Cervical cancer, Breast cancer, Lung cancer, Colorectal cancer |
| Research Fields: | Cancer;Cell biology;Genetics;Stem cell biology |
| Application: | ChIP ; ELISA ; IHC ; IP ; WB |
| Target: | c Myc epitope tag |
| Reactivity: | Human |
| Clone: | 9A |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Monoclonal antibody raised against sequence of c-Myc, a proto-oncogene heavily implicated in a variety of (hematopoietic) cancers, which has been used in cancer research to detect and understand the distribution of the c-Myc oncogene product. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Immunogen: | Synthetic peptide (AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA – 32 aa) corresponding to 408-439 of Human c-Myc conjugated to KLH. |
| Immunogen Uniprot ID: | P01106 |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Anti c-Myc is raised against the proto-oncogene c-Myc, analogous to the avian v-Myc gene a very strong proto-oncogene often found to be upregulated in cancer. Aberrant and constitutive expression of c-Myc has been particularly implicated in the upregulation of genes involved in cellular proliferation and has been identified in cancers including carcinoma of cervix, colon, breast, lung and stomach, plus a translocation leading to Burkitt's lymphoma. The gene product of c-Myc (p62) is upregulat… |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | Store at -20° C frozen. Avoid repeated freeze / thaw cycles |
| Shipping conditions: | Dry ice |
| References: |
Si et al. 2018. Int J Biol Sci. 14(2):165-177. PMID: 29483835. Oh et al. 2018. Cell Rep. 25(7):1681-1692.e4. PMID: 30428339. Aldon et al. 2018. Cell Rep. 24(12):3324-3338.e5. PMID: 30232012. Rodrguez-Escudero et al. 2018. Sci Rep. 8(1):7732. PMID: 29769614. Mateos-Gomez et al. 2015. Nature. 518(7538):254-7. PMID: 25642960. Mammalian polymerase promotes alternative NHEJ and suppresses recombination. Zhang et al. 2014. Genes Dev. 28(8):829-34. PMID: 24736842. The diab… |
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