Recognises mouse DNGR-1, also known as CLEC9A, which is a highly specific marker of the CD8a+ and the CD103+ DC subsets, as well as a receptor able to recognise a preformed signal exposed on necrotic cells.
| Institute |
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| Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| SKU: | 151704 |
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| Product description: | Recognises mouse DNGR-1, also known as CLEC9A, which is a highly specific marker of the CD8a+ and the CD103+ DC subsets, as well as a receptor able to recognise a preformed signal exposed on necrotic cells. |
| Alternate name: | C-Type Lectin Domain Family 9 Member A; HEEE9341; UNQ9341; DNGR-1; CD37; DNGR1 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Immunogen: | RBL-2H3 cells expressing mouse DNGR-1 fused to an HA epitope |
| Myeloma used: | Y3.AG.1.2.3 |
| Cat. #: | 151704 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Immunology; Stem cell biology |
| Application: | WB |
| Target: | Mouse DNGR1 |
| Reactivity: | Mouse |
| Clone: | 397 |
| Host: | Rat |
| Class: | Monoclonal |
| Target background: | Recognises mouse DNGR-1, also known as CLEC9A, which is a highly specific marker of the CD8a+ and the CD103+ DC subsets, as well as a receptor able to recognise a preformed signal exposed on necrotic cells. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Joffre et al. 2010. Eur J Immunol. 40(5):1255-65. PMID: 20333625. Efficient and versatile manipulation of the peripheral CD4+ T-cell compartment by antigen targeting to DNGR-1/CLEC9A. Sancho et al. 2009. Nature. 458(7240):899-903. PMID: 19219027. Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Sancho et al. 2008. J Clin Invest. 118(6):2098-110. PMID: 18497879. Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin. |
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