Anti-CLEC2 [17D9]

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Monoclonal antibody used to study the expression pattern of CLEC-2 receptor.

Contributors

Inventor Institute
Caetano Reis e Sousa Cancer Research UK, London Research Institute: Lincoln's Inn Fields
SKU: 151581
Product description: Monoclonal antibody used to study the expression pattern of CLEC-2 receptor.
Conjugation: Unconjugated
Isotype: IgG2b
Immunogen: RBL-2H3 cells stably expressing HA-tagged mouse CLEC-2
Immunogen Uniprot ID: Q9P126
Myeloma used: Y3.AG.1.2.3
Cat. #: 151581
Provenance and Ownership: The Anti-CLEC2 [17D9] is owned by Cancer Research UK. CancerTools supplies the Anti-CLEC2 [17D9] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-CLEC2 [17D9] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements.
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Immunology; Tissue-specific biology
Application: FACS ; WB
Target: Ctype lectin-like receptor (CLEC2)
Reactivity: Mouse
Clone: 17D9
Host: Rat
Class: Monoclonal
Target background: CLEC-2 belongs to a sub-family of C-type lectin receptors that signal through Syk via a single YxxL motif (hemITAM). CLEC-2 is highly expressed on resting platelets and megakaryocytes and at a lower level on several hematopoietic cells including monocytes, macrophages, dendritic cells, and granulocytes. CLEC-2 acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. CLEC-2 also functions as an activation receptor on monocytes and neutrophils to induce phagocytosis and proinflammatory cytokine production. This antibody can be used as a selective agonist of CLEC-2 and also to study its expression pattern.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
Shipping conditions: Dry ice
References:

Kerrigan et al. 2009. J Immunol. 182(7):4150-7. PMID: 19299712.

CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils.

Images

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Specificity of anti-mouse CLEC-2 monoclonal antibody 17D9 for FACS.

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