Antibody CP9/19 recognises only the intra-strand cross-links formed by cisplatin between adjacent purines.
| Inventor | Institute |
|---|---|
| Michael Tilby | The Institute of Cancer Research; Newcastle University |
| Cat. #: | 151464 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Genetics |
| Application: | ELISA ; FACS ; IHC ; IP ; DB |
| Target: | Cisplatin modified native DNA |
| Clone: | CP9/19 |
| Host: | Rat |
| Class: | Monoclonal |
| Product description: | Antibody CP9/19 recognises only the intra-strand cross-links formed by cisplatin between adjacent purines. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Immunogen: | Cisplatin modified native DNA |
| Myeloma used: | Y3.AG.1.2.3 |
| Target background: | This antibody enables the quantification of cisplatin-induced adducts on DNA. This antibody has also been recently used for isolation of DNA fragments carrying adducts to enhance the sensitivity of subsequent PCR-based analyses and is central to ongoing studies of variation in the nature of cisplatin adducts formed in different cell lines. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Powell et al. 2015. Sci Rep. 5:7975. PMID: 25609656. 3D-DIP-Chip: a microarray-based method to measure genomic DNA damage. Kothandapani et al. 2012. Exp Cell Res. 318(16):1973-86. PMID: 22721696. Downregulation of SWI/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity. Kothandapani et al. 2011. J Biol Chem. 286(16):14564-74. PMID: 21357694. Novel role of base excision repair in mediating cisplatin cytotoxicity. Meczes et al. 2005. Biochem Pharmacol. 70(12):1… |
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