Clone By114 reacts with a phosphatidylinositol (PI) linked protein with a molecular mass of 90 kD on granulocyte and squamous epithelium. This antibody is useful in differentiating normal cells from neoplastic cells of granulocyte origin. CD66CE is useful in differentiating normal cells from neoplastic cells of granulocyte origin. By114 may be used to study Paroxysmal Nocturnal Hemoglobinuria (PNH).
| Inventor | Institute |
|---|---|
| Karen Pulford | University of Oxford |
| SKU: | 151368 |
|---|---|
| Product description: | Clone By114 reacts with a phosphatidylinositol (PI) linked protein with a molecular mass of 90 kD on granulocyte and squamous epithelium. This antibody is useful in differentiating normal cells from neoplastic cells of granulocyte origin. CD66CE is useful in differentiating normal cells from neoplastic cells of granulocyte origin. By114 may be used to study Paroxysmal Nocturnal Hemoglobinuria (PNH). |
| Alternate name: | Carcinoembryonic Antigen Related Cell Adhesion Molecule 5 & 6; Meconium Antigen 1; CEA; Carcinoembryonic Antigen; CD66e & c |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Immunogen: | B cell Lymphoma cells |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Cat. #: | 151368 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology |
| Application: | FACS ; IHC ; IF ; IP ; WB |
| Target: | Carcinoembryonic antigen-related cell adhesion molecules 5 & 6 (CEACAM5, CD66e; CEACAM6, CD66c)CD66 C and E subtypes (NCA) |
| Reactivity: | Human |
| Clone: | By114 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Clone By114 reacts with a phosphatidylinositol (PI) linked protein with a molecular mass of 90 kD on granulocyte and squamous epithelium. This antibody is useful in differentiating normal cells from neoplastic cells of granulocyte origin. CD66CE is useful in differentiating normal cells from neoplastic cells of granulocyte origin. By114 may be used to study Paroxysmal Nocturnal Hemoglobinuria (PNH). |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Tooze et al. 1995. Exp Hematol. 23(14):1484-91. PMID: 8542935. The novel monoclonal antibody By114 helps detect the early emergence of a paroxysmal nocturnal hemoglobinuria clone in aplastic anemia. Mayne et al. 1993. Br J Haematol. 83(1):30-8. PMID: 8435334. Antibody By114 is selective for the 90 kD PI-linked component of the CD66 antigen: a new reagent for the study of paroxysmal nocturnal haemoglobinuria. |
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