Anti-CEACAM1 (CD66a) [11-1H]

CEACAM1 is known as an epithelial tumour suppressor and an angiogenic growth factor.

Contributors

Inventor Institute
Bernhard B. Singer LeukoCom
SKU: 153378
Product description: Carcinoembryonic antigen related cell adhesion molecules (CEACAM) (CD66a) belong to the immunoglobulin superfamily. They are highly glycosylated proteins with the typical N-terminal variable Ig-like domain followed by 0-6 constant Ig-like domains. A hydrophobic transmembrane domain with a cytoplasmic tail anchors CEACAM1 to the cell membrane. CEACAM1 is known as an epithelial tumour suppressor and an angiogenic growth factor.
Alternate name: CD66, BGP 1, BGP, CD66a, Carcinoembryonic Antigen Related Cell Adhesion Molecule 1; CD66a Antigen; BGP1; BGP; Biliary Glycoprotein 1; Antigen CD66
Conjugation: Unconjugated
Isotype: IgG1 kappa
Immunogen: Recombinant soluble rat CEACAM1-Fc produced in HEK293 cells
Myeloma used: NS1/0
Cat. #: 153378
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer; Cell biology
Application: ELISA ; FACS ; IHC ; IF ; IP ; WB
Target: CEACAM1
Reactivity: Rat
Clone: [11-1H]
Host: Mouse
Class: Monoclonal
Target background: Carcinoembryonic antigen related cell adhesion molecules (CEACAM) (CD66a) belong to the immunoglobulin superfamily. They are highly glycosylated proteins with the typical N-terminal variable Ig-like domain followed by 0-6 constant Ig-like domains. A hydrophobic transmembrane domain with a cytoplasmic tail anchors CEACAM1 to the cell membrane. CEACAM1 is known as an epithelial tumour suppressor and an angiogenic growth factor.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Singer et al. 2005. Eur J Immunol. 35(6):1949-59. PMID: 15909305.

CEACAM1 (CD66a) mediates delay of spontaneous and Fas ligand-induced apoptosis in granulocytes.

Singer et al. 2000. Cancer Res. 60(5):1236-44. PMID: 10728682.

The tumor growth-inhibiting cell adhesion molecule CEACAM1 (C-CAM) is differently expressed in proliferating and quiescent epithelial cells and regulates cell proliferation.

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Immunohistochemistry

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